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104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft 2006
Abstract
Abstract
SO.06.04 Ageing of retinal vessels Lanzl I.1, Bock A.2, Schmidt-Trucksäß A.2, Vilser W.3, Halle M.2, Kotliar K.1
1Augenklinik, Klinikum rechts der Isar der Technischen Universität München, 2Lehrstuhl für Präventive Sportmedizin, Technische Universität München, 3Biomedical Engineering, Technische Universität Ilmenau Background: In healthy human subjects vessels undergo aging processes. Whether medically and ophthalmologically healthy subjects of different age groups demonstrate different reactions to a luminance flicker stimulus was examined by means of dynamic Vessel Analyzer (IMEDOS).
Methods: In 156 healthy subjects retinal vessel reactions to flicker to the right eye were examined. The volunteers were divided in three age groups: Young (52 persons, 20-37 years; 29,1±5.2 years), Middle Age (52 persons, 38-52 years, 44.5±4.3 years) and seniors (53-70 years, 61.3±5.1 years). In all subjects retinal vessel diameter was assessed along a chosen segment. After 50 sec. baseline recording a monochromatic rectangular luminance flicker (530-600 Nm) with a frequency of 12,5 cycles per second was applied for 20 sec and repeated 3 times. The vessel reaction was tracked and analyzed.
Results: In all subjects a repeatable dilation of the retinal arteries and a successive reactive constriction were observed. The difference in the arterial mean dilation between the middle age group and seniors was statistically significant. The difference of the arterial mean constriction between the young and the two older groups was statistically significant. Older subjects demonstrated less vasomotion.
Discussion: The retinal vessel reaction to luminance flicker in "healthy old persons” differs from that of younger subjects. In particular the regulation to reach baseline levels after stimulation is temporally retarded and damped in older humans. These results are important to know when investigating vessels reactions in diseased eyes. Also the retinal vasculature corresponds to small cerebral vessels in its structure. Therefore possibly luminance flicker stimulation of the retinal vessels might represent a method to assess central vessel status.
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