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104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft 2006
Abstract
Abstract
FR.03.08 Bevacizumab (AvastinTM) in patients with subfoveal choroidal neovascularization: prognostic factors Lux A., Menrath E., Heussen F. M. A., Joeres S., Joussen A. M.
Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne Objective: To determine the anatomical and functional outcome after injection of AvastinTM (Bevacizumab) in eyes with neovascular AMD.
Methods: In a prospective interventional case series, 26 eyes of 26 patients with visual loss due to choroidal neovascularization (4 classic membranes, 1 minimally classic, 15 occult membranes, 2 Drusen with PED, 2 myopic and idiopathic CNVs, and 2 parapapillary CNVs) were treated with intravitreal injections of 1.25 mg (0.05ml) Bevacizumab. Best-corrected visual acuity and reading ability, fluorescein and indocyanine green angiography as well as optical coherence tomography and fixation stability were performed pre- and postoperatively to evaluate lesion size, functional outcome and need of re-treatment within a 3 months follow-up period.
Results: No significant ocular or systemic side effects were observed. At the last follow-up 11 of 26 eyes (42%) demonstrated complete resolution of retinal edema. A reduction of retinal thickness was seen in 11 more cases. In 3 eyes the retinal edema remained stable, in 1 patient an increase was noted. A second injection of Bevacizumab was performed in 9 cases. At the last follow-up, mean VA improved from 0,58±0,40 logMAR to 0,43±0,44 logMAR. Reading acuity improved from 0,61±0,34 logRAD to 0,52±0,32 logRAD.
Conclusions: Short-term results suggest that intravitreal bevacizumab (1.25 mg) is well tolerated and associated with improvement in VA, decreased retinal thickness by OCT, and reduction in angiographic leakage in most patients. While this heterogenous group and the short term follow-up only allow for cautious conclusions, responsiveness to bevacizumab seems independent of the lesion-type but rather depends on the size of the membrane and its activity.
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