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104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft 2006
Abstract
Abstract
DO.02.06 Humanistic burden and health resource utilization among neovascular age-related macular degeneration (AMD) patients in Germany Meister A.1, Zlateva G.2, Xu X.3, Pauleikhoff D.1
1Department of Ophthalmology, St. Franziskus-Hospital, Münster; 2Pfizer Inc., USA; 3Covance Market Access Services, USA Objective: This study was undertaken in 4 EU countries and Canada to assess the burden of bilateral neovascular AMD on patient-reported functioning and health resource utilization (HRU) as compared to elderly controls without AMD.
Methods: Of the total 401 bilateral neovascular AMD patients and 471 elderly non-AMD (control) subject, 83 AMD patients and 93 controls were recruited in Germany. Physicians recorded demographic and treatment information. Patients completed a telephone survey of the National Eye Institute Visual Function Questionnaire (NEI VFQ-25), the EuroQol (EQ-5D), the Hospital Anxiety and Depression Scale (HADS), and history of falls, fractures and HRU. The impact of AMD on functioning and HRU was compared between AMD patients and controls using chi-square tests, analysis of variance, and multivariate regression models.
Results: The mean age of AMD patients in Germany was 77, and 64% were female. Similar to the other countries, in Germany AMD patients reported substantially worse quality of life (QOL) than the control patients after adjusting for age, gender, and comorbid diseases. The adjusted mean (95% CI) NEI VFQ overall scale scores was 51.31 (37.72, 64.90) in AMD patients, which was considerably lower than the control patients 96.31 (82.75, 109.87), p<0.001. AMD patients reported significantly more anxiety and depression symptoms than control patients on the HADS scales (anxiety score: 6.7 vs. 5.2, p=0.054; depression scores: 6.2 vs. 2.7, p<0.001) after adjusting for covariates. AMD had an impact on general quality of life as assessed by the EQ-5D: 0.69 vs. 0.79 for AMD vs. controls respectively, p =0.036. The impact of AMD was also seen in other health-related problems, such as falls and depression treatment. The proportion of AMD patients who fell in the past 12 months was three times higher than that of control patients (13.3% vs. 4.3%, p=0.031).
Conclusions: Bilateral AMD patients in Germany reported substantially worse QOL, poorer vision-related functioning, and more anxiety and depression symptoms compared to a control group of subjects without AMD. These findings are similar to the overall study sample across 5 countries.
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