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104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft 2006
Abstract
Abstract
SA.02.09 Correlation of visual function and morphology in human ocular toxoplasmosis Scherrer J.1, Iliev M. E.1, Halberstadt M.1, Kodjikian L.2, Garweg J. G.1
1University of Bern, Switzerland; 2University of Lyon, France Objective: Hitherto, the functional impact of ocular toxoplasmosis (OT) on visual acuity and the visual field has not been systematically evaluated. The aim of the present study was to assess the representativity of these two functional tests.
Methods: Of 139 patients with inactive OT invited for an ocular examination, 61 could be recruited for our evaluation. The examination involved a measurement of best-corrected visual acuity, automated visual-field testing, a slit-lamp inspection, and dilated ophthalmoscopy. We adopted the WHO definition of low vision and blindness.
Results: 8 of the 61 patients (13%) presented with bilateral OT. Amongst the 69 eyes, 65 (94.1%) manifested toxoplasmic damage to the visual field, and 28 (41%) a reduced visual acuity, revealing perimetric findings to be more sensitive (p<0.001). Functional damage corresponded morphologically to the toxoplasmic lesions in 48 (70%) and 23 (33%) instances, respectively. Moderate to severe visual-field damage was encountered in 65% of the eyes, whereas a visual acuity below 20/60 occurred in 28%. In 6 (4%) of the latter, the visual acuity was less than 3/60. In two patients, a relevant reduction in visual function occurred in both eyes.
Conclusions: OT had a functional impact on the visual field in more than 94% of eyes. As a functional test, an evaluation of visual-field damage has a sufficient sensitivity to consider its use in the assessment of the clinical course of disease, i.e. detection of intercurrent functionally represented subclinical reactivation as well as of prophylactic and therapeutic strategies for OT patients.
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