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104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft 2006
Abstract
Abstract
SO.13.01 Empiric and evidence-based options for the treatment of chronic endogenous uveitis Garweg J. G.
University of Bern, Switzerland Objective: The treatment of chronic endogenous uveitis has included the use of corticosteroids since the early fifties, and these still resemble the first line option in the treatment, once an infectious etiology has been excluded.
Methods: Since the sixties, broad experience has been collected with antiproliferative and alcylating agents, and since the eighties several immunosuppressants have been employed in the therapy of endogenous uveitis. It has been recognised that the therapeutic response is not only related to a specific uveitic entity, but also to the genetic background of the individual.
Results: Therefore, there do not exist clear guide lines for therapy, and for most of the drugs, controlled studies are not available. Vitrectomy and intravitreal drug delivery have been added as local options on top or in case of failure of these systemic therapies. The advent of biological agents, however, i.e. the introduction of interferon and TNF alpha blocking agents, has opened a new era in the treatment of immunogenetic and autoimmune disorders.
Conclusions: Evidence-based knowledge and personal experience have been reviewed to provide an update on the therapeutic strategy for chronic endogenous uveitis.
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