104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft 2006
Abstract
Abstract
DO.02.12 High resolution optical coherence tomography (HR-OCT) findings in dry and early stages of neovascular age-related macular degeneration Geitzenauer W., Simader C., Michels S., Ahlers C., Schmidt-Erfurth U.
Department of Ophthalmology, Medical University of Vienna Objective: Visualization of changes in dry and early stages of wet age-related macular degeneration with three-dimensional optical coherence tomography (HR-OCT).
Methods: Using a high-resolution spectral domain OCT system with an axial resolution of 6 µm and up to 20.000 A scans per second allows evaluation of a 6 x 6 mm central retinal area. The scan patterns used consisted of 256x256x1024 and 512x128x1024 voxels. In contrast to conventional OCT examination with 6 radial lines all voxels in the examined field are realistically depicted.
Results: Small drusen appeared as localized elevation of the retinal pigment epithelium (RPE) with intact architecture of the photoreceptor band and all intraretinal layers. In large drusen RPE elevation was associated with disruption of the photoreceptor band. Early forms of choroidal neovascularization showed morphological changes of the choriocapillaris-RPE complex. The location of the neovascular membrane breaking through the RPE band is identifiable and often accompagnied by a localized subretinal fluid.
Conclusions: High resolution optical coherence tomography shows the pathognomonic changes and distinct progression of age-related macular degeneration. Already in eyes with large drusen a destruction of the photoreceptor integrity can be found. Due to the high resolution of the chosen examination technique histological changes like fine RPE elevation and disruptions of the photoreceptor band can be clearly identified. Raster scanning technology allows detailed demonstration of adjacent anatomical structures.
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