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104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft 2006
Abstract
Abstract
SO.04.13 Photodynamic therapy of choroidal neovascular vessels in myopia: Effects, therapeutic recommends and prognostic factors Padge B., Meister A., Pauleikhoff D.
Departement of Opthalmology, St. Franziskus Hospital, Muenster Objective: The VIP trial examined the effects of PDT on subfoveal CNV in patients with pathologic myopia having a visual acuity (VA) >0.1. The rate of stabilized VA (<3 lines vision loss) was 86% after in mean 3,2 PDTÂ’s. In this retrospective study we examined the reproductability of the VIP trial results in clinical practice and analized prognostic factors for visual prognosis.
Methods: 50 patients with myopia (36 females, 14 males; age 20-92 y; follow-up 3-33 monthes) and a visual acuity of 0.05 – 0,5 (Lesions with mean of greatest linear dimension 1,93 mm) were included and treated by PDT. The therapeutic outcome (visual loss <3 lines) after 12 mo was analyzed in respect to number of PDT treatments, the effect of age, initial visual acuity, size of lesion area and clinical parameters as bleeding or pigmentation.
Results: After 12 mo the visual acuity was stabilized in 72,2% (mean number of PDT 2,08) of the patients. Regarding the initial visual acuity the group with a visual acuity <0,2 demonstrated a stabilisation in 81% (mean number of PDT 1.48), while the group with a visual acuity of ³0.2 achieved stabilisation in 59% of the eyes (mean number of PDT 1.76). Considering the area of the lesion, stabilisation was seen in 81% for lesions with area 1 DA. Most often stabilisation of VA was achieved after 1 PDT treatment (86%). In contrast patients treated twice or more with PDT stabilisation could only be observed in 55%. The patient’s age, a subretinal hemorrhage or hyperpigmentation of the lesion did not influence the outcome after PDT.
Conclusions: In comparison with the VIP trial after 12 mo the number of stabilizing in the present study was in a similar range, but the number of PDT treatments was lower than in the VIP trial. These results demonstrate that in routine clinical practice similar results as in prospective trials can be achieved. In addition the area of the CNV and the initial visual acuity are the only important prognostic factors influencing the visual outcome and may be considered recommending PDT treatment in myopic patients.
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