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104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft 2006
Abstract
Abstract
SO.09.12 Prevention of posterior capsule opacification by in vivo ablation of lens epithelial cells in rabbit eyes with the ARC-Laser-Photolysis-System Pollhammer M.1, Cursiefen C.1, Rummelt C.1, Walker R.2, Thyzel R.2, Kruse F. E.1
1Department of Ophthalmology, University of Erlangen-Nürnberg; 2A.R.C. Laser GmbH, Nürnberg Objective: In recent in-situ experiments we showed, that a nearly complete ablation of lens epithelial cells from the lens capsule of enucleated porcine eyes with the ARC-Laser-Photolysis-System is possible. Aim of this study is to evaluate this device in an in-vivo setting as a an intraoperative method to prevent posterior capsule opacification.
Methods: A group of 12 New Zealand White rabbits underwent standard cataract surgery on both eyes and were divided into a control- and a laser ablation group. Before injecting a foldable lens into the capsular bag, the hand piece of the ARC-LPS was inserted into the eyes of the laser group and a medium of 204 (±36) pulses with an energy of 7mJ were applied onto the anterior and equatorial lens capsule in a meander like pattern. Postoperatively, a topical therapy with a mixture of antibiotic and steroid eye drops was performed. The eyes were enucleated after six weeks and cut between the limbus and equatorial region for evaluation. Digital images from a posterior Miyake/Apple view were taken and planimetry was performed within the optic with the EPCO-software system.
Results: The evaluation of the digital images showed a significant reduction of EPCO-scores / posterior capsule opacification in the treatment group (=0,33) compared to the control group (=0,69)(p=0,035). In 2 of 8 eyes little bleedings from iris vessels occurred.
Conclusions: Laser ablation with the ARC-LPS as an intraoperative PCO-prevention device leads to a significant reduced formation of posterior capsule opacification after 6 weeks. Complications like bleeding from iris vessels can be minimized by reduction of laser energy, so that this system could be used during human standard cataract surgery for preventing posterior capsule opacification.
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